150 Club

Your Longevity Starts Here.

AI-Powered Genetic Intelligence Platform

PolyU Micro Fund 2025-26 Cohort 2 Confidential
Speaker
We are 150 Club. We're building the intelligence layer between your DNA test and your daily health decisions.

The Problem

The “So What?” Gap

84
pages of DNA data.
Zero actionable protocols.

Static Reports

DNA tests deliver 84-page PDFs that sit unread. Genetic risk data alone produces zero measurable behavior change.

Data Silos

Genetic reports, blood panels, and wearable data exist in separate worlds. No platform connects them.

One-Time & Dead

DNA is tested once but health is dynamic. Reports never update when new research reclassifies your variants.

Speaker
Tens of millions of people have taken DNA tests. Almost nobody knows what to do with the results.

The Opportunity

A Market Starved for Action

100M+
DNA tests taken globally
24% CAGR
~0%
behavior change from genetic risk data alone
Proven in RCTs
$5,000+
cost of functional medicine consultation
Only alternative

“The market is saturated with genetic data but starved for actionable protocols. This is the gap we close.”

Speaker
Over 100 million DNA tests taken globally. Behavior change from the results? Essentially zero.

The Solution

From Dead PDF to Living Protocol

150 Club transforms static DNA reports into personalized, evolving health protocols — powered by AI, grounded in verified science.

Before
84-page PDF report filed away
Generic risk percentages
No connection to blood work
Never updates with new research
English only for APAC users
CircleDNA Report
84 pages · PDF
Diabetes Risk: 23% Heart: Moderate 574 variants
No actionable steps provided
After — 150 Club
Personalized supplement stacks
Nutrition & exercise protocols
DNA + blood panel cross-analysis
Living updates as science evolves
Full Chinese-language support
Your Dashboard
80
Health
Today's Protocol
Vitamin D34,000 IU
Omega-32g/day
Methylfolate800mcg
✓ Updated 2 days ago with new research
Speaker
We turn this dead PDF into a living, personalized health protocol. Supplements, nutrition, exercise — all tailored to your DNA.

How It Works

From Upload to Protocol in Minutes

01

Upload

Drop your CircleDNA PDF. Our parser extracts every variant automatically.

< 2 min
Upload Report
CircleDNA_WES_Report.pdf
7.3 MB
Analyze My DNA
02

Analyze

AI cross-references variants against ClinVar, PharmGKB & our knowledge base.

< 3 min
Risk Overview
574 traits
Low 389
Moderate 142
High 43
80 Diet
60 Fitness
90 Wellness
03

Protocol

Personalized supplements, nutrition & exercise — grounded in evidence.

< 10 min
Your Protocol
Essential Vitamin D3 4,000 IU/day
Essential Omega-3 (EPA/DHA) 2g/day
Recommend Methylfolate (5-MTHF) 800mcg/day
Mediterranean Diet Pattern
Power/HIIT Training Focus
Speaker
Three steps. Upload, analyze, protocol. Ten minutes total from raw DNA data to personalized health plan.

Core Technology

4-Layer Health Intelligence Architecture

Genetic Layer
Static
Your DNA blueprint — SNPs, pharmacogenomics, polygenic risk scores. Immutable data, continuously re-interpreted.
Biomarker Layer
Periodic
Blood panels, metabolic markers, hormones. Validates whether genetic risks have materialized.
Lifestyle Layer
Continuous
Wearable data — HRV, sleep, activity, nutrition. Measures protocol adherence in real time.
Environmental Layer
Contextual
Air quality, UV index, pollen, location. Adapts protocols to real-world conditions.

The LLM never invents health claims. It only interprets what these four verified data layers have established.

Speaker
Four verified data layers ground every AI output. The LLM never invents — it only interprets.

Market Opportunity

The Size of the Prize

TAM Consumer Genomics + AI in Genomics + Longevity $7–12B
SAM APAC DNA test-takers seeking optimization $200–500M
SOM HK + SG Year 1 $2–5M
27%
APAC Genetic Testing CAGR
30–45%
AI in Genomics CAGR
$314B
Longevity Economy by 2030
$16.4B
China Genetic Testing by 2033
Speaker
Consumer genomics growing to $10 billion. AI in genomics at 30-45% CAGR. Our year-one beachhead: $2-5 million.

Beachhead Strategy

Why Hong Kong First

CircleDNA HQ

Prenetics is headquartered in HK. Highest DNA test penetration in APAC. Massive aftermarket of untapped CircleDNA users.

Bilingual Market

English/Chinese population lets us validate both language models simultaneously before regional expansion.

Minimal Regulation

No specific DTC genetic testing legislation. Advisory-only approach. Most permissive market in APAC for wellness platforms.

Premium & Connected

High willingness to pay for health optimization. Gateway to Singapore, Taiwan, and the broader APAC longevity economy.

Speaker
Hong Kong is ideal. CircleDNA HQ, bilingual market, most permissive regulation in Asia.

Business Model

Free Insight, Paid Protocol

Free Tier
Capture & Convert
Upload DNA report
Basic genetic summary
Top risk highlights
Data capture for conversion
Premium
$19–$49/month
Personalized supplement stacks
Nutrition & exercise protocols
Blood panel cross-analysis
Living updates & protocol evolution

Family Plans: $39–$89/mo  |  Practitioner SaaS: $99–$299/mo (Phase 2)

85%+
Gross Margin
>4:1
LTV:CAC
<3 mo
Payback
$35/mo
Target ARPU
Speaker
Free tier captures data and demonstrates value. Premium is where willingness-to-pay is highest. 85% gross margins.

Competitive Landscape

The Only Complete Solution

AI-Powered
Multi-Report
Chinese
Protocol Engine
Living Updates
SelfDecode
Partial
Promethease
Nucleus
Partial
CircleDNA
Report
150 Club

The only platform combining all five capabilities in a single product — with native Chinese support and ancestry-calibrated algorithms for APAC populations.

Speaker
SelfDecode is the closest — but no Chinese, no ancestry calibration for Asian populations. We're the only platform with all five.

Defensibility

5-Layer Competitive Moat

1

Multi-Source Ingestion

Accept reports from any DNA provider. We are the aggregation layer.

2

4-Layer Ground Truth

Deterministic data model compounds with every data point a user adds.

3

Chinese-Language AI

First-to-market with native Chinese genetic interpretation + TCM integration.

4

Ancestry-Calibrated

Algorithms tuned for East Asian populations using ChinaMAP & regional biobanks.

5

Family Network Effects

Each family member added multiplies engagement and raises switching costs.

No Western competitor can credibly replicate Chinese-language AI interpretation + TCM-genomics integration for 1.5B Chinese speakers.
Speaker
Five layers of defensibility. The critical one: we're first to market with Chinese-language AI genetic interpretation.

Traction & Validation

Built, Not Just Planned

Working Prototype

Live
PDF parsing pipeline for CircleDNA
AI/RAG engine with hallucination guards
Frontend dashboard UI
End-to-end upload → protocol flow

Validated Problem

Confirmed
Real CircleDNA WES reports tested
Family DNA + blood panel cross-analysis
Confirmed the “so what?” gap firsthand
Production-ready architecture defined

Advisory Network

Active
Domain advisors engaged
Business Master Plan completed
14-week Phase 1 sprint plan ready
GCP-integrated tech stack finalized
Speaker
Working prototype, validated problem with real DNA reports, and advisory network in place. This isn't a concept — it's code.

Go-to-Market

Capture High-Intent Users at the Moment of Curiosity

CircleDNA Aftermarket

Highest conversion

Target users who spent $400–$600 on a DNA test and are searching “what do my results mean?”

Longevity Communities

Community-led

Bryan Johnson’s Don’t Die community (13K+ Discord). Biohacking communities in HK and SG.

Practitioner Network

B2B referral

Free practitioner accounts for functional medicine doctors. Trusted recommendation channel with high conversion.

Content-Led Growth

SEO + social

Definitive content library for DNA report interpretation in English and Chinese. Captures organic traffic at peak curiosity.

Speaker
Highest-conversion channel: CircleDNA users who already spent $400-600 and are searching for what to do next. Zero paid acquisition needed.

The Team

Built by Builders Who’ve Shipped Together

Billy Lui
Billy Lui
Co-Founder
VC-Backed Founder

10 years leading venture-backed software startups. Product design & management expert across enterprise, blockchain, and AI. Backed by Silicon Valley VCs.

Ex-HK Team Swimmer HKSI Elite Athlete Biohacker
Andy Lam
Andy Lam
Co-Founder
VC-Backed Founder

18 years in systems engineering. Built front-office trading systems, portfolio analytics, and big data platforms. Backed by VCs and Plug and Play.

MSc Applied Math BA Computing Adtech & Data Infra
Eric Cheung
Eric Cheung
Co-Founder
VC-Backed Founder

17 years full-stack systems engineering. AWS data pipelines, Kubernetes, Spark ML, blockchain. Backed by Silicon Valley VCs.

BSc Applied Physics 2× MSc (Math + CS) 17 Years Engineering
8+ years building venture-backed startups together. Proven co-founders backed by Silicon Valley VCs and Plug and Play.
Speaker
Three co-founders with 8+ years building venture-backed startups together. All backed by VCs — Andy by VCs and Plug and Play, Billy and Eric by Silicon Valley VCs. Billy is a former Hong Kong team swimmer turned biohacker — this problem is personal.

The Ask

PolyU Micro Fund support + HKSTP Incubation pathway

What We Deliver
Phase 1 MVP: CircleDNA PDF ingestion → English-language protocol generation
100–200 beta users in Hong Kong validating product-market fit
Lean Launchpad milestones aligned to Jun–Jul 2026 programme
Foundation for Chinese-language expansion and APAC scale

The next great health platform won’t generate more data.
It will make existing data actionable.

150 Club  |  Your Longevity Starts Here.

Speaker
We're asking for Micro Fund support and a pathway to HKSTP Incubation. The next great health platform won't generate more data. It will make existing data actionable. That's 150 Club.
150 Club